Efficacy of Inhaled Budesonide and Ambroxol Hydrochloride in Pediatric Pneumonia and Its Impact on Inflammatory Response: Systematic Review

Abstract

Background: This systematic review evaluates the efficacy and safety of nebulized budesonide combined with ambroxol hydrochloride for the treatment of pediatric pneumonia. Methods: Adhering to PRISMA 2020, this review synthesizes findings from randomized controlled trials and observational studies, focusing on clinical outcomes, inflammatory markers, and the overall effectiveness of the combined treatment. Results: Findings indicate significant improvements in clinical symptoms, reduced hospitalization time, and favorable changes in inflammatory markers such as C-reactive protein (CRP) and white blood cell (WBC) counts. The combination therapy demonstrates a higher total effective rate compared to standard treatments, suggesting a promising approach for managing pediatric pneumonia. Conclusion: However, this review emphasizes the need for further large-scale studies to confirm these findings and establish standardized treatment protocols.