The Analysis Study of the Efficacy and Safety of Electroencephalography-Guided General Anesthesia to Minimize Postoperative Delirium : A Comprehensive Systematic Review

Abstract

Background: Postoperative delirium (POD) is a prevalent and serious complication following surgery in older adults. This study aims to compare the efficacy and safety of electroencephalography-guided general anesthesia to minimize postoperative delirium. Methods: Following PRISMA 2020 guidelines, this systematic review focused exclusively on full-text articles published in English between 2014 and 2024. Result: The study conducted a comprehensive review of over 100 publications sourced from reputable databases, including ScienceDirect, SagePub, and PubMed. Following an initial screening, eight publications were identified as warranting more in-depth analysis. Consequently, a thorough review of these selected studies was performed to ensure a detailed and rigorous evaluation. Conclusion: pEEG-guided anesthesia or targeting lighter pEEG levels did not consistently reduce postoperative delirium (POD) compared to usual care or deeper pEEG levels. However, a secondary analysis showed a significant reduction in POD with pEEG guidance.