Exploring Perspectives and Challenges in Lip Rejuvenation: A Systematic Review

Abstract

Background: While extensive literature exists on various cosmetic surgical procedures for the upper third of the face—such as facelifts, blepharoplasties, and rhinoplasty—there is a notable lack of information regarding perioral lip rejuvenation. This article aims to review the current literature on lip rejuvenation techniques and associated perioral procedures. Methods: Following PRISMA 2020 guidelines, this systematic review focused exclusively on full-text articles published in English between 2014 and 2024. Result: The study conducted a comprehensive review of over 1,000 publications sourced from reputable databases, including ScienceDirect, SagePub, and PubMed. Following an initial screening, five publications were identified as warranting more in-depth analysis. Conclusion: Integrating perioral rejuvenation with lip enhancement procedures yields more aesthetically pleasing results compared to lip rejuvenation alone. However, the efficacy of any cosmetic intervention—whether surgical or non-surgical—can be influenced by the nature and composition of the products employed. It is strongly recommended to utilize FDA-approved products to mitigate potential side effects. Further research is essential to investigate the long-term effects and possible adverse outcomes associated with newer therapies, particularly regarding stem cell applications, which may carry risks such as tumor development.