Linking Gut and Nasal Microbiota to Allergic Rhinitis: A Comprehensive Systematic Review

Abstract

Background: Various minimally invasive techniques for Allergic rhinitis is a chronic, non-infectious inflammation of the nasal mucosa triggered by specific IgE responses. In recent years, growing interest has emerged in the human microbiome as a promising target for treating this condition. Methods: Following PRISMA 2020 guidelines, this systematic review focused exclusively on full-text articles published in English between 2014 and 2024. Result: The study conducted a comprehensive review of over 1,000 publications sourced from reputable databases, including ScienceDirect, SagePub, and PubMed. Following an initial screening, five publications were identified as warranting more in-depth analysis. Consequently, a thorough review of these selected studies was performed to ensure a detailed and rigorous evaluation. Conclusion: The review highlights the potential immune-modulatory function of the gut microbiome in allergic rhinitis, suggesting that alterations in gut bacteria may influence immune responses that exacerbate or mitigate nasal inflammation. However, existing research has not yet established a clear causal link between specific microbiota shifts and the development or severity of allergic rhinitis.