A Comparative Study of Olopatadine and Ketotifen in the Management of Allergic Conjunctivitis: A Systematic Review

Abstract

Background: Allergic conjunctivitis is a prevalent non-traumatic inflammatory condition affecting millions globally, primarily caused by environmental allergens. Characterized by symptoms such as itching, redness, and tearing, it significantly impacts patients' quality of life. Methods: Following PRISMA guidelines, eligible studies were identified, focusing on peer-reviewed RCTs published between 2014 and 2024. Data on treatment efficacy, safety, and symptom relief were analyzed. Results: The analysis revealed that olopatadine often outperforms ketotifen in symptom relief and tolerability. Conclusion: Despite the promising findings, the review acknowledges limitations such as study heterogeneity and short follow-up durations. Further research is warranted to enhance understanding of long-term efficacy and safety profiles of these treatments, ultimately improving management strategies for allergic conjunctivitis.