The Analysis Study of Effectiveness of The Fixed-dose Combination of Perindopril and Amlodipine in Managing Hypertension: A Comprehensive Systematic Review

Abstract

Background: Cardiovascular diseases (CVDs) are recognized as the leading causes of mortality globally, with hypertension emerging as a primary risk factor. FDC therapy consolidates two or more antihypertensive agents into a single pill, simplifying the treatment regimen. Methods: Following PRISMA 2020 guidelines, this systematic review focused exclusively on full-text articles published in English between 2014 and 2024. Result: The study conducted a comprehensive review of over 100 publications sourced from reputable databases, including ScienceDirect, SagePub, and PubMed. Following an initial screening, eight publications were identified as warranting more in-depth analysis. Consequently, a thorough review of these selected studies was performed to ensure a detailed and rigorous evaluation. Conclusion: Perindopril/amlodipine FDC is effective in lowering blood pressure, outperforming both monotherapy and placebo. While it is associated with mild side effects, the combination may improve patient adherence and overall cost-effectiveness, although cost-effectiveness data are currently lacking