The Analysis Study of Skin Carcinoma Treatment with Photodynamic Therapy: A Comprehensive Systematic Review

Abstract

Background: Rosacea is a chronic inflammatory skin condition that typically develops in the third decade of life but can occur at any age. Isotretinoin, traditionally used for acne, has been studied for rosacea due to its anti-inflammatory and sebum-reducing properties. However, concerns over adverse effects, including teratogenicity, have limited its use. Methods: Following PRISMA 2020 guidelines, this systematic review focused exclusively on full-text articles published in English between 2014 and 2024. Result: The study conducted a comprehensive review of over 100 publications sourced from reputable databases, including ScienceDirect, SagePub, and PubMed. Following an initial screening, eight publications were identified as warranting more in-depth analysis. Consequently, a thorough review of these selected studies was performed to ensure a detailed and rigorous evaluation. Conclusion: Low-dose isotretinoin is an effective treatment for moderate-to-severe or recalcitrant rosacea. All studies reviewed indicate that LDI improves symptoms with generally mild, dose-dependent side effects. LDI should be considered a valuable therapeutic option for rosacea, especially for patients who do not respond to traditional treatments.