The Analysis Study of Acute Postoperative Discomfort Following Dental Extractions in Adults: A Comprehensive Systematic Review

Abstract

Background: The aim of this systematic review was to evaluate the comparative effectiveness of pharmacological treatments for managing pain after simple and surgical tooth extractions. Methods: Following PRISMA 2020 guidelines, this systematic review focused exclusively on full-text articles published in English between 2014 and 2024. Result: The study conducted a comprehensive review of over 100 publications sourced from reputable databases, including ScienceDirect, SagePub, and PubMed. Following an initial screening, eight publications were identified as warranting more in-depth analysis. Consequently, a thorough review of these selected studies was performed to ensure a detailed and rigorous evaluation. Conclusion: The most effective interventions for pain relief in individuals undergoing surgical tooth extractions were found to be ibuprofen 200 to 400 mg combined with acetaminophen 500 to 1,000 mg, acetaminophen 650 mg with oxycodone 10 mg, ibuprofen 400 mg, and naproxen 400 to 440 mg. In contrast, oxycodone 5 mg, codeine 60 mg, and tramadol 37.5 mg with acetaminophen 325 mg showed no better effectiveness than placebo.