The Analysis Study of Outcomes of Regenerative Endodontic Treatments for Necrotic Immature and Mature Permanent Teeth : A Comprehensive Systematic Review

Abstract

Background: Pulp necrosis in both immature and mature permanent teeth presents unique treatment challenges, particularly as this condition can halt root development in immature teeth. This systematic review aims to reevaluate the clinical efficacy of REPs in necrotic immature versus mature permanent teeth. Methods: Following PRISMA 2020 guidelines, this systematic review focused exclusively on full-text articles published in English between 2014 and 2024. Result: The study conducted a comprehensive review of over 100 publications sourced from reputable databases, including ScienceDirect, SagePub, and PubMed. Following an initial screening, eight publications were identified as warranting more in-depth analysis. Consequently, a thorough review of these selected studies was performed to ensure a detailed and rigorous evaluation. Conclusion: Regenerative endodontic procedures demonstrate comparable success rates for necrotic immature and mature permanent teeth, though challenges remain. Further investigation into stem cell dynamics, pulp sensitivity, and discoloration causes is essential to optimize treatment outcomes and patient satisfaction.